. Author manuscript; available in PMC: 2013 Oct 11.

Published in final edited form as: J Med Chem. 2012 Sep 20;55(19):8392–8408. doi: 10.1021/jm300780p

Table 4.

In vitro hTRPV1 Antagonistic Activities for 2-Piperazinyl and 2-Morpholinyl Pyridines

	K_i [CAP] (nM)	IC₅₀ [pH] (nM)		K_i [CAP] (nM)	IC₅₀ [pH] (nM)
79	0.8	25.1	90	2.5	44.5
80	0.7	27.8	91	1.4	108
81	WE	WE	92	WE	WE
82	146	WE	93	2.1	117
83	21.6	WE	94	4.1	WE
84	0.7	30.7	95	2.8	WE
85	3.4	39.2	96	8.8	634
86	3.3	38.3	97	1.3	169
87	2.4	34	98	1.43	1090
88	1.1	23.1	99	WE	WE
89	2.3	117