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. Author manuscript; available in PMC: 2013 Oct 11.
Published in final edited form as: J Med Chem. 2012 Sep 20;55(19):8392–8408. doi: 10.1021/jm300780p

Table 5.

In vitro hTRPV1 Antagonistic Activities for 2 and 49S to multiple activators

Activators 2
(nM)		 49S
(nM)
CAP (f)Ki 28 0.2
pH (IC50) 1281 6.3
Heat 45°C (IC50) 174 0.8
NADA (f)Ki 6.6 0.01