Table 2.
Associations between occupational exposure to trichloroethylene, benzene, and formaldehyde, polymorphisms in immune genes, and the risk for non-Hodgkin lymphoma
| SNPs | NHL overall
|
B-cell lymphoma
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nonexposed
|
Exposed
|
Diffuse large B-cell lymphoma
|
Follicular lymphoma
|
|||||||||||
| Nonexposed
|
Exposed
|
Nonexposed
|
Exposed
|
|||||||||||
| Co | Ca | ORa | Co | Ca | ORa (95% CI) | Ca | ORa | Ca | ORa (95% CI) | Ca | ORa | Ca | ORa (95% CI) | |
| Trichloroethylene | ||||||||||||||
| IL12A_07 (rs582054) | ||||||||||||||
| TT | 145 | 122 | 1.0 | 26 | 14 | 0.70 (0.34, 1.42) | 40 | 1.0 | 4 | 0.59 (0.19, 1.85) | 26 | 1.0 | 4 | 0.82 (0.25, 2.72) |
| AT or AA | 332 | 270 | 1.0 | 31 | 51 | 2.09 (1.28, 3.42) | 82 | 1.0 | 21 | 2.66 (1.42, 4.96) | 65 | 1.0 | 10 | 1.71 (0.78, 3.77) |
| Pfor interaction | 0.0090 | 0.0119 | 0.3498 | |||||||||||
| Benzene | ||||||||||||||
| IL12A_07(rs582054) | ||||||||||||||
| TT | 133 | 115 | 1.0 | 38 | 21 | 0.62 (0.34, 1.12) | 35 | 1.0 | 9 | 0.87 (0.38, 1.99) | 27 | 1.0 | 3 | 0.35 (0.10, 1.25) |
| AT or AA | 309 | 254 | 1.0 | 54 | 67 | 1.46 (0.98, 2.17) | 79 | 1.0 | 24 | 1.76 (1.02, 3.04) | 59 | 1.0 | 16 | 1.51 (0.80, 2.83) |
| Pfor interaction | 0.0201 | 0.1786 | 0.0468 | |||||||||||
| IL15_02(rs10833) | ||||||||||||||
| CC | 199 | 172 | 1.0 | 37 | 29 | 0.90 (0.53, 1.53) | 51 | 1.0 | 13 | 1.41 (0.69, 2.86) | 40 | 1.0 | 3 | 0.36 (0.11, 1.24) |
| CT or TT | 244 | 197 | 1.0 | 55 | 59 | 1.31 (0.86, 1.98) | 63 | 1.0 | 20 | 1.39 (0.77, 2.50) | 46 | 1.0 | 16 | 1.55 (0.81, 2.98) |
| Pfor interaction | 0.2460 | 0.9211 | 0.0406 | |||||||||||
| IL10_17 (rs1800890) | ||||||||||||||
| TT | 219 | 148 | 1.0 | 42 | 40 | 1.39 (0.86, 2.25) | 41 | 1.0 | 17 | 2.13 (1.11, 4.12) | 30 | 1.0 | 10 | 1.66 (0.75, 3.69) |
| AT or AA | 270 | 262 | 1.0 | 66 | 60 | 0.93 (0.63, 1.37) | 84 | 1.0 | 18 | 0.87 (0.49, 1.56) | 63 | 1.0 | 15 | 0.94 (0.50, 1.76) |
| Pfor interaction | 0.2104 | 0.0415 | 0.2753 | |||||||||||
| TNF_02 (rs1800629) | ||||||||||||||
| GG | 359 | 286 | 1.0 | 71 | 74 | 1.30 (0.91, 1.87) | 84 | 1.0 | 22 | 1.31 (0.77, 2.25) | 65 | 1.0 | 22 | 1.66 (0.95, 2.89) |
| AG or AA | 128 | 126 | 1.0 | 37 | 27 | 0.67 (0.38, 1.18) | 41 | 1.0 | 13 | 1.07 (0.51, 2.23) | 29 | 1.0 | 3 | 0.32 (0.09, 1.13) |
| Pfor interaction | 0.0762 | 0.7017 | 0.0206 | |||||||||||
| Formaldehyde | ||||||||||||||
| IL6_01 (rs1800795) | ||||||||||||||
| GG | 180 | 145 | 1.0 | 61 | 66 | 1.43 (0.94, 2.19) | 27 | 1.0 | 30 | 3.64 (1.97, 6.71) | 43 | 1.0 | 8 | 0.54 (0.23, 1.25) |
| CG or CC | 249 | 189 | 1.0 | 100 | 110 | 1.43 (1.03, 2.00) | 61 | 1.0 | 40 | 1.56 (0.98, 2.48) | 38 | 1.0 | 30 | 1.79 (1.04, 3.07) |
| Pfor interaction | 0.9810 | 0.0279 | 0.0280 | |||||||||||
| IL6_04 (rs1800797) | ||||||||||||||
| GG | 173 | 145 | 1.0 | 60 | 67 | 1.39 (0.91, 2.13) | 24 | 1.0 | 30 | 3.97 (2.12, 7.45) | 42 | 1.0 | 8 | 0.53 (0.23, 1.24) |
| AG or AA | 243 | 175 | 1.0 | 95 | 106 | 1.52 (1.08, 2.14) | 59 | 1.0 | 41 | 1.67 (1.04, 2.66) | 36 | 1.0 | 26 | 1.67 (0.95, 2.95) |
| Pfor interaction | 0.7575 | 0.0311 | 0.0345 | |||||||||||
| IL10_17 (rs1800890) | ||||||||||||||
| TT | 182 | 118 | 1.0 | 79 | 70 | 1.40 (0.94, 2.08) | 23 | 1.0 | 35 | 3.69 (2.03, 6.69) | 29 | 1.0 | 11 | 0.91 (0.43, 1.93) |
| AT or AA | 251 | 214 | 1.0 | 85 | 108 | 1.49 (1.06, 2.10) | 65 | 1.0 | 37 | 1.64 (1.02, 2.64) | 52 | 1.0 | 26 | 1.45 (0.84, 2.48) |
| Pfor interaction | 0.7915 | 0.0373 | 0.3319 | |||||||||||
Ca, cases; CI, confidence interval; Co, controls; NHL, non-Hodgkin lymphoma; OR, odds ratio; SNPs, single nucleotide polymorphisms.
a
Adjusted for age and race.