Table I.
Distribution of demographics, lifestyle and risk factor characteristics within the AARP study population contributing to categories of aspirin and non-aspirin NSAID use patterns
| Aspirin Use | Non-Aspirin NSAIDs Use | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-Regular | Regular | Non-Regular | Regular | ||||||
| N | % | N | % | N | % | N | % | ||
| N | 63,864 | 31,311 | 68,988 | 25,946 | |||||
| Average age at entry (yr) | 61.6 | 62.4 | 62.0 | 61.5 | |||||
| Follow-up (person-yr) | 569,795 | 276,635 | 614,179 | 230,111 | |||||
| Race/Ethnicity | |||||||||
| White Non-Hispanic | 57,915 | 90.7 | 29,071 | 92.8 | 62,878 | 91.1 | 23,911 | 92.2 | |
| Other | 5,225 | 8.2 | 1,883 | 6.0 | 5,340 | 7.7 | 1,730 | 6.7 | |
| Unknown | 724 | 1.1 | 357 | 1.1 | 770 | 1.1 | 305 | 1.2 | |
| Education | |||||||||
| High school diploma or less | 24,698 | 38.7 | 12,663 | 40.4 | 26,912 | 39.0 | 10,353 | 39.9 | |
| Post-secondary school | 37,601 | 58.9 | 17,788 | 56.8 | 40,396 | 58.6 | 14,879 | 57.3 | |
| Unknown | 1,565 | 2.5 | 860 | 2.7 | 1,680 | 2.4 | 714 | 2.8 | |
| Body Mass Index | |||||||||
| <25 kg/m2 | 29,625 | 46.4 | 13,475 | 43.0 | 33,102 | 48.0 | 9,906 | 38.2 | |
| 25–30 kg/m2 | 19,444 | 30.4 | 10,089 | 32.2 | 21,168 | 30.7 | 8,268 | 31.9 | |
| 30+ kg/m2 | 13,050 | 20.4 | 6,947 | 22.2 | 12,803 | 18.6 | 7,169 | 27.6 | |
| Unknown | 1,745 | 2.7 | 800 | 2.6 | 1,915 | 2.8 | 603 | 2.3 | |
| Smoking | |||||||||
| Never | 29,063 | 45.5 | 13,493 | 43.1 | 31,293 | 45.4 | 11,166 | 43.0 | |
| Former | 24,938 | 39.0 | 12,561 | 40.1 | 26,602 | 38.6 | 10,832 | 41.7 | |
| Current | 8,301 | 13.0 | 4,403 | 14.1 | 9,351 | 13.6 | 3,293 | 12.7 | |
| Unknown | 1,562 | 2.4 | 854 | 2.7 | 1,742 | 2.5 | 655 | 2.5 | |
| Alcohol Consumption | |||||||||
| <1 drink/day | 54,513 | 85.4 | 26,438 | 84.4 | 58,629 | 85.0 | 22,105 | 85.2 | |
| 1–3 drinks/day | 7,376 | 11.5 | 3,762 | 12.0 | 8,127 | 11.8 | 2,989 | 11.5 | |
| 3+ drinks/day | 1,975 | 3.1 | 1,111 | 3.5 | 2,232 | 3.2 | 852 | 3.3 | |
| Age at menarche | |||||||||
| <13 yrs | 30,673 | 48.0 | 15,270 | 48.8 | 32,653 | 47.3 | 13,181 | 50.8 | |
| 13–14 yrs | 27,169 | 42.5 | 13,134 | 41.9 | 29,752 | 43.1 | 10,452 | 40.3 | |
| 15+ yrs | 5,841 | 9.1 | 2,830 | 9.0 | 6,389 | 9.3 | 2,253 | 8.7 | |
| Unknown | 181 | 0.3 | 77 | 0.2 | 194 | 0.3 | 60 | 0.2 | |
| Parity | |||||||||
| Nulliparous | 10,117 | 15.8 | 4,683 | 15.0 | 11,235 | 16.3 | 3,541 | 13.6 | |
| One | 6,463 | 10.1 | 3,097 | 9.9 | 7,143 | 10.4 | 2,390 | 9.2 | |
| Two | 16,723 | 26.2 | 7,897 | 25.2 | 17,888 | 25.9 | 6,660 | 25.7 | |
| Three+ | 30,358 | 47.5 | 15,520 | 49.6 | 32,500 | 47.1 | 13,265 | 51.1 | |
| Unknown | 203 | 0.3 | 114 | 0.4 | 222 | 0.3 | 90 | 0.3 | |
| Age First Birth | |||||||||
| Nulliparous | 9,665 | 15.1 | 4,459 | 14.2 | 10,705 | 15.5 | 3,392 | 13.1 | |
| <20 yrs | 9,695 | 15.2 | 5,031 | 16.1 | 10,040 | 14.6 | 4,624 | 17.8 | |
| 20–24 yrs | 27,462 | 43.0 | 13,962 | 44.6 | 29,578 | 42.9 | 11,765 | 45.3 | |
| 25–29 yrs | 12,269 | 19.2 | 5,727 | 18.3 | 13,405 | 19.4 | 4,540 | 17.5 | |
| 30+ yrs | 4,276 | 6.7 | 1,872 | 6.0 | 4,686 | 6.8 | 1,442 | 5.6 | |
| Unknown | 497 | 0.8 | 260 | 0.8 | 574 | 0.8 | 183 | 0.7 | |
| Age at Menopause | |||||||||
| Premenopausal | 4,006 | 6.3 | 1,637 | 5.2 | 3,876 | 5.6 | 1,759 | 6.8 | |
| <45 yrs | 16,163 | 25.3 | 8,725 | 27.9 | 17,223 | 25.0 | 7,592 | 29.3 | |
| 45–49 yrs | 14,699 | 23.0 | 7,209 | 23.0 | 16,038 | 23.2 | 5,818 | 22.4 | |
| 50–54 yrs | 23,374 | 36.6 | 11,056 | 35.3 | 25,741 | 37.3 | 8,611 | 33.2 | |
| 55+ yrs | 5,312 | 8.3 | 2,532 | 8.1 | 5,780 | 8.4 | 2,043 | 7.9 | |
| Unknown | 310 | 0.5 | 152 | 0.5 | 330 | 0.5 | 123 | 0.5 | |
| Hysterectomy Status | |||||||||
| Never | 48,568 | 76.0 | 23,101 | 73.8 | 53,098 | 77.0 | 18,377 | 70.8 | |
| Ever | 15,014 | 23.5 | 8,085 | 25.8 | 15,584 | 22.6 | 7,473 | 28.8 | |
| Unknown | 282 | 0.4 | 125 | 0.4 | 306 | 0.4 | 96 | 0.4 | |
| Post-menopausal Hormone Use | |||||||||
| Never | 29,631 | 46.4 | 13,701 | 43.8 | 33,394 | 48.4 | 9,780 | 37.7 | |
| Estrogen only, <10 yr | 6,982 | 10.9 | 3,659 | 11.7 | 7,321 | 10.6 | 3,311 | 12.8 | |
| Estrogen only, 10 yr+ | 4,215 | 6.6 | 2,535 | 8.1 | 4,353 | 6.3 | 2,377 | 9.2 | |
| Estrogen + progesterone, <10 yr | 14,840 | 23.2 | 7,137 | 22.8 | 15,332 | 22.2 | 6,619 | 25.5 | |
| Estrogen + progesterone, 10 yr+ | 4,743 | 7.4 | 2,575 | 8.2 | 4,963 | 7.2 | 2,355 | 9.1 | |
| Unknown | 3,453 | 5.4 | 1,704 | 5.4 | 3,625 | 5.3 | 1,504 | 5.8 | |
| Oral Contraceptive Use | |||||||||
| <1 yr | 37,307 | 58.4 | 18,765 | 59.9 | 41,407 | 60.0 | 14,471 | 55.8 | |
| 1 yr to <10 yr | 19,632 | 30.7 | 9,290 | 29.7 | 20,355 | 29.5 | 8,524 | 32.9 | |
| 10 yr+ | 6,543 | 10.2 | 3,050 | 9.7 | 6,792 | 9.8 | 2,801 | 10.8 | |
| Unknown | 382 | 0.6 | 206 | 0.7 | 434 | 0.6 | 150 | 0.6 | |
| First Degree Relatives with Ovarian Cancer | |||||||||
| No | 48,488 | 75.9 | 23,480 | 75.0 | 52,186 | 75.6 | 19,627 | 75.6 | |
| Yes | 3,379 | 5.3 | 1,663 | 5.3 | 3,548 | 5.1 | 1,482 | 5.7 | |
| Unknown | 11,997 | 18.8 | 6,168 | 19.7 | 13,254 | 19.2 | 4,837 | 18.6 | |
| Second Degree Relatives with Ovarian Cancer | |||||||||
| No | 57,856 | 90.6 | 28,309 | 90.4 | 62,658 | 90.8 | 23,333 | 89.9 | |
| Yes | 3,379 | 5.3 | 1,698 | 5.4 | 3,517 | 5.1 | 1,539 | 5.9 | |
| Unknown | 2,629 | 4.1 | 1,304 | 4.2 | 2,813 | 4.1 | 1,074 | 4.1 | |
| First Degree Relatives with Breast Cancer | |||||||||
| No | 44,583 | 69.8 | 21,540 | 68.8 | 47,898 | 69.4 | 18,063 | 69.6 | |
| Yes | 8,529 | 13.4 | 4,142 | 13.2 | 9,173 | 13.3 | 3,495 | 13.5 | |
| Unknown | 10,752 | 16.8 | 5,629 | 18.0 | 11,917 | 17.3 | 4,388 | 16.9 | |
| Second Degree Relatives with Breast Cancer | |||||||||
| No | 50,074 | 78.4 | 24,675 | 78.8 | 54,450 | 78.9 | 20,123 | 77.6 | |
| Yes | 11,161 | 17.5 | 5,332 | 17.0 | 11,725 | 17.0 | 4,749 | 18.3 | |
| Unknown | 2,629 | 4.1 | 1,304 | 4.2 | 2,813 | 4.1 | 1,074 | 4.1 | |