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Chemical structures of aromatase substrate and inhibitors. Androst-4-ene-3,17-dione (androstenedione, ASD) is the substrate, androsta-1,4-diene-3,17-dione (ASDD) a substrate analogue, and formestane a steroidal aromatase inhibitor. Exemestane (EXM) is the steroidal AI and letrozole (LTZ) and anastrozole (ANZ) are the nonsteroidal AIs used in the treatment of postmenopausal estrogen-dependent breast cancer. The color code is the following: carbon, black; nitrogen, blue; oxygen, red.
