Figure 3.

Invertebrate Alp protein sequences and conserved syntenies. (A) Alp genes amplified independently in vertebrate chordate and non-vertebrate chordate lineages, and in deuterostomes (including vertebrates) and protostomes (including insects). (B) Conserved syntenies among paralogons including human, coelacanth, and gar Alp genes. Alp genes in red, and paralogs of other gene families, such as Ece1, Ecel1, and Ece2 genes and Eif4 genes shown in unifying colors. Arrows represent direction of transcription. (C) Conserved syntenies in four paralogons in the human genome, only two of which have ALP genes. The figure shows four human chromosomes, Hsa1, Hsa2, Hsa3, and Hsa7, with lines between chromosomes connecting paralogs. Each square represents a gene; small gray squares from which no lines extend are genes without paralogs in the regions shown.