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. 2012 Oct 12;3:314. doi: 10.3389/fimmu.2012.00314

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Copyright © 2012 Yang, Wandler, Postlethwait and Guillemin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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A model for the history of Alp genes in vertebrates. A chromosome segment in a non-vertebrate chordate contained Ece, Alp, and Eif4 genes and duplicated twice in the vertebrate genome duplication events (VGD1 and VGD2) to make four paralogons, one of which lost its Alp gene. After the divergence of rayfin and lobefin bony fish lineages, the teleost genome duplication event (TGD) did not result in further extant Alp genes, but tandem duplications (TD) in the Alpi locus provided a number of separate Alp genes.