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Self-seeding concept of cancer growth and metastasis (a) dislodging and reattachment of a primary tumor cell at the primary site, (b) dislodging, intravasation, circulation, then extravasation back to the primary site, (c) dislodging, intravasation, circulation, then extravasation to a metastatic site, and (d) self-seeding from a metastatic site following path A or path B
