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. Author manuscript; available in PMC: 2013 Oct 3.
Published in final edited form as: J Am Chem Soc. 2012 Sep 21;134(39):16430–16433. doi: 10.1021/ja307628w

Scheme 2. Reagents and Conditions.

Scheme 2

(a) NBS, HF/pyridine, CH2Cl2, rt, 91%; (b) TMSCH2CH2OH, NIS, AgOTf, CH2Cl2, 3Å MS, −25 °C, 94%; (c) TFA, CH2Cl2, H2O, rt, 5 h, 67%; (d) CCl3CN, DBU, CH2Cl2, 0 °C, 87%.