Table 3. Student's t-test for comparison of mean (±SD) values for linear variables by diagnosis and CCT subgroup.
|
Total sample (n=169) |
Thin CCT (n=56)
(465–541 μm) |
Intermediate CCT (n=56)
(542–572 μm) |
Thick CCT (n=57)
(573–668 μm) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POAG n=81 | OH n=88 | P-value | POAG n=35 | OH n=21 | P-value | POAG n=32 | OH n=24 | P-value | POAG n=14 | OH n=43 | P-value | |
| Age (years) | 69.64±9.04 | 62.45±7.60 | <0.001 | 68.66±9.55 | 64.0±6.7 | 0.06 | 72.22±8.81 | 62.96±8.86 | <0.001 | 66.21±6.93 | 61.42±7.25 | 0.03 |
| CCT (μm) | 543.27±36.60 | 566.39±34.96 | <0.001 | 510.40±18.88 | 521.71±15.51 | 0.03 | 555.62±9.84 | 553.63±8.55 | 0.43 | 597.21±25.70 | 595.33±20.71 | 0.78 |
| CH (mm Hg) | 7.58±1.38 | 9.19±1.67 | <0.001 | 7.04±1.35 | 8.33±1.71 | 0.007 | 7.85±1.23 | 9.18±1.48 | 0.001 | 8.31±1.38 | 9.63±1.62 | 0.008 |
| CRF (mm Hg) | 8.81±1.90 | 11.10±1.81 | <0.001 | 8.10±1.07 | 10.52±1.82 | <0.001 | 8.70±1.49 | 10.56±1.30 | <0.001 | 10.81±1.97 | 11.67±1.88 | 0.15 |
| AL (μm) | 24.30±0.99 | 24.29±1.11 | 0.97 | 24.18±0.89 | 24.27±1.15 | 0.74 | 24.46±1.16 | 24.13±1.31 | 0.35 | 24.24±0.81 | 24.39±0.99 | 0.62 |
| A1C (%) | 6.13±0.87 | 6.59±1.25 | 0.012 | 6.29±0.96 | 6.64±1.33 | 0.29 | 5.86±0.85 | 6.46±1.01 | 0.04 | 6.30±0.51 | 6.63±1.34 | 0.41 |
| GAT-IOP (mm Hg) | 17.78±5.87 | 20.35±4.45 | 0.001 | 17.33±4.96 | 21.36±3.72 | 0.001 | 16.81±4.86 | 19.54±3.95 | 0.03 | 21.11±8.74 | 20.30±5.00 | 0.67 |
| DCT-IOP (mm Hg) | 20.49±6.24 | 22.92±4.81 | 0.002 | 20.72±5.14 | 23.91±4.06 | 0.004 | 18.94±5.27 | 22.31±4.08 | 0.01 | 23.45±9.43 | 22.78±5.49 | 0.74 |
| IOPcc (mm Hg) | 21.38±6.19 | 22.15±4.90 | 0.26 | 21.25±5.43 | 23.18±4.53 | 0.06 | 20.06±4.74 | 20.87±4.51 | 0.52 | 24.74±9.40 | 22.37±5.21 | 0.24 |
| IOPg (mm Hg) | 18.20±6.38 | 20.89±5.20 | 0.002 | 17.40±5.52 | 20.24±6.07 | 0.03 | 17.01±4.79 | 19.58±4.02 | 0.04 | 22.95±9.32 | 21.94±5.23 | 0.61 |
| MD (dB) | −6.11±5.25 | −0.09±1.38 | <0.001 | −6.07±4.74 | 0.35±1.42 | <0.001 | −6.64±5.42 | −0.03±1.23 | <0.001 | −5.03±6.22 | −0.35±1.42 | <0.001 |
| PSD (dB) | 6.13±3.64 | 1.88±0.59 | <0.001 | 6.07±3.64 | 1.90±0.59 | <0.001 | 6.41±3.57 | 1.94±0.57 | <0.001 | 5.64±3.98 | 1.83±0.62 | <0.001 |
| RNFL (μm) | 66.49±15.69 | 91.98±12.85 | <0.001 | 65.51±14.91 | 91.34±11.46 | <0.001 | 63.11±14.57 | 88.08±13.12 | <0.001 | 76.7±0.15 | 94.5±13.0 | <0.001 |
| CDR | 0.77±0.15 | 0.51±0.16 | <0.001 | 0.76±0.15 | 0.53±0.17 | <0.001 | 0.79±0.15 | 0.51±0.18 | <0.001 | 0.74±0.15 | 0.51±0.15 | <0.001 |
| Tx (n) | 52/81 | 23/88 | <0.001 | 21/35 | 7/21 | 0.05 | 22/32 | 7/24 | 0.001 | 9/14 | 9/43 | 0.002 |
| (%) | 64 | 26 | 60 | 33 | 69 | 29 | 64 | 21 | ||||
Abbreviations: A1C, average glycosylated hemoglobin; AL, axial length; CCT, central corneal thickness; CDR, cup-to-disc ratio; CH, corneal hysteresis; CRF, corneal resistance factor; DCT-IOP, intraocular pressure as measured by Pascal Dynamic Contour Tonometer; GAT-IOP, intraocular pressure as measured by Goldmann applanation tonometer; IOPcc, corneal-compensated intraocular pressure as measured by Ocular Response Analyzer; IOPg, Goldmann-correlated intraocular pressure as measured by Ocular Response Analyzer; MD, mean devation; OH, ocular hypertension; PSD, pattern standard deviation; POAG, primary open-angle glaucoma; RNFL, retinal nerve fiber layer thickness; Tx, treated with anti-glaucoma agent.