Table 2.

Effect of L + E + P on Cancer-Related miRNAs.

miRNA	Function	Fold Change	Targets
miR144	Tumor-suppressive	→772941-fold	Notch-1
miR-133b	Tumor-suppressive	→177812-fold	c-MET, FSCN1
miR-1	Tumor-suppressive	→66913-fold	Cyclin D2, CXCR4, SDF1α
miR-122	Proapoptotic	→9741-fold	Cyclin B1
miR-34c	Tumor-suppressive	→6700-fold	E2F3, Bcl2, c-MET
miR-200c	Tumor-suppressive	→5077-fold	ZEB1, ZEB2, FN1, MSN
miR-127	Tumor-suppressive	→4067-fold	E2F3, Notch-1, Bcl2
miR-335	Tumor-suppressive	→3983-fold	COLA1, SOX4, TNC
miR-124	Tumor-suppressive	→1389-fold	ROCK2, EZH2, CDK6
miR-181a	Tumor-suppressive	→962-fold	K-ras, Bcl2
miR-7	Tumor-suppressive	→849-fold	Bcl2, EGFR, IGF1R
miR-215	Tumor-suppressive	→820-fold	DTL
miR-15a	Tumor-suppressive	→786-fold	Fgf2, cyclin E2
Let-7d	Tumor-suppressive	→4-fold	Twist
miR-20a	Oncogenic	↓13587-fold	APP
miR-21	Oncogenic	↓1260-fold	TMP1, Pdcd4, MARCKS
miR-9	Oncogenic	↓173-fold	E-cadherin
miR-29b	Oncogenic	↓48-fold	PTEN
miR-181b	Oncogenic	↓39-fold	PTEN, TIMP3

Effects of PJ on the levels of metastasis-related miRNAs. RNA from PC3 cells treated with L + E + P at 8 µg/ml for 12 hours was submitted to miRNA PCR array analysis. Relative miRNA levels are shown as fold change compared with untreated control.