Figure 1.

Clonogenic survival of A549 (A) and SNB19 (B) cell lines as functions of the radiation dose and the duration of postradiation exposure to an Hsp90 inhibitor. DMSO-treated controls (empty squares), NVP-AUY922-treated (filled circles) cells, and NVP-BEP800-treated cells (filled triangles) were irradiated with single IR doses of up to 10 Gy. At the indicated time after irradiation, cells were plated for the colony survival tests. Survival curves were fitted by an LQ equation (Equation 1). The experiment was repeated at least three times. Significant differences between control and cells treated with NVP-AUY922 or NVP-BEP800 are indicated (*P < .05, **P < .01).