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General description of our prodrug activation strategy by antibody-catalyzed retro-aldol/retro-Michael reaction sequence. The activation sequence catalyzed by 38C2 is depicted for the drug-masking linker. Catalytic cleavage of the trigger by retro-aldol/retro-Michael reactions of the linker is followed by spontaneous decarboxylation, cyclization, and release of the free drug.
