Table 1.

Baseline Characteristics of Participants in the WACS Cognitive Cohort ^*

Characteristics	Folic acid / B6 / B12 (n=1002) Mean (SD; range)	Placebo (n=1007) Mean (SD; range)	p-value †
Age at randomization,years	71.3 (4.2; 65.3–89.9)	71.3 (4.2; 65.3–90.0)	0.96
Age at initial cognitive assessment,years	72.5 (4.2; 66.1–90.9)	72.5 (4.2; 66.1–91.2)	0.99
Total Physical Activity (kcal/week)	905 (1112; 0 – 7825)	920 (1185; 0– 19017)	0.36
Body mass index (kg/m2)	29.0 (5.9; 15.4 – 55.6)	28.6 (5.5; 16.3 – 54.7)	0.37
	Median (25th–75th percentile)	Median (25th–75th percentile)
Total Folate intake from diet and supplements (μg/day)‡	455 (323 – 700)	455 (319–685)	0.84
Total Vitamin B6 intake from diet and supplements (mg/day)	2.6 (1.9 – 3.9)	2.7 (1.9 – 4.01)	0.34
Total Vitamin B12 intake from diet and supplements (μg/day)	7.3 (4.8 – 11.1)	7.4 (4.7 – 11.1)	0.76
Total Alcohol intake (g/day)	0 (0 – 2.9)	0 (0 –3.5)	0.59
	Percent	Percent
Highest attained education
LPVN/AD/RN §	70.4	70.3
BA/MA/DR §	29.6	29.7	0.97
Cigarette smoking
Never smoker (%)	46.5	47.7
Past smoker (%)	46.6	44.6
Current smoker (%)	6.9	7.8	0.58
Postmenopausal hormone therapy
Never user (%)	39.9	40.3
Past user (%)	24.8	24.0
Current user (%)	35.3	35.7	0.93
History of MI	21.7	22.1	0.79
History of Stroke	9.7	8.4	0.33
History of Revascularization Surgery	23.4	22.5	0.67
History of Angina	50.5	47.8	0.22
History of Transient Ischemic Attack	15.4	16.9	0.36
History of Diabetes	18.9	20.1	0.50
History of Hypertension	88.6	89.2	0.69
History of Hyperlipidemia	79.2	80.6	0.44

^*Characteristics as of randomization

^†For tests of differences between the two groups for all continuous variables, Wilcoxon rank-sum tests were used, and for categorical variables, chi-square tests were used

^‡Folate intake has been calculated as folate equivalents

^§LPVN: Licensed practical or vocational nurse; AD: Associate's degree; RN: Registered nurse; BA: Bachelor's degree; MA: Master's degree; DR: Doctoral degree