Table 2.

Cognitive function at each cognitive assessment, by B vitamin treatment

Treatment Assignment
Cognitive Test	Folic acid / B6 / B12		Placebo
Cognitive Assessment	No. of subjects	Mean (SE) *	No. of subjects	Mean (SE) *	Mean difference [B vitamin Group - Placebo Group] (95% CI) †
PRIMARY ENDPOINT: Global score ‡
1	1002	0.00 (0.02)	1007	−0.01 (0.02)	0.01 (−0.05, 0.07)
2	911	0.06 (0.03)	923	0.01 (0.02)	0.05 (−0.01, 0.12)
3	850	−0.04 (0.03)	845	−0.07 (0.03)	0.02 (−0.06, 0.10)
4	521	−0.02 (0.03)	532	−0.07 (0.03)	0.05 (−0.04,0.14)
KEY SECONDARY ENDPOINT: Verbal memory score ‡
1	1002	0.00 (0.02)	1007	0.00 (0.02)	0.01 (−0.06, 0.07)
2	911	0.07 (0.03)	923	0.01 (0.03)	0.06 (−0.02, 0.13)
3	850	0.03 (0.03)	845	0.03 (0.03)	0.00 (−0.07, 0.08)
4	521	0.03 (0.03)	532	−0.04 (0.03)	0.06 (−0.03, 0.16)
TICS score ‡
1	1002	34.35 (0.10)	1007	34.38 (0.10)	−0.04 (−0.31, 0.24)
2	911	34.39 (0.11)	923	34.30 (0.10)	0.09 (−0.21, 0.39)
3	850	34.05 (0.11)	845	33.94 (0.13)	0.12 (−0.22, 0.45)
4	521	33.94 (0.13)	532	33.64 (0.15)	0.30 (−0.09, 0.69)
Category fluency score
1	1000	16.65 (0.16)	1007	16.32 (0.15)	0.34 (−0.09, 0.76)
2	909	16.82 (0.17)	921	16.49 (0.16)	0.33 (−0.12, 0.79)
3	846	15.65 (0.17)	840	15.33 (0.18)	0.32 (−0.16, 0.80)
4	519	16.46 (0.20)	530	16.57 (0.19)	−0.11 (−0.65,0.43)

^*Least squares means and standard errors

^†From longitudinal linear models of least square means of cognitive performance at each assessment

^‡TICS = Telephone Interview of Cognitive Status;

Verbal score is a composite score of the z-scores of the immediate and delayed recalls of both the TICS 10-word and the East Boston Memory Test;

Global score is a composite score of the z-scores of TICS, immediate and delayed recalls of the East Boston Memory Test, category fluency, delayed recall of the TICS 10-word list