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. 2012 Oct 12;7(10):e46979. doi: 10.1371/journal.pone.0046979

Table 1. Clinico-pathological characteristics and CFC-recovery following immunomagnetic cell separation.

Patient Age PSA Prior Treatment Clinical stage Gleason/Bone scan mets No. of cores involved % core involvement (range) CD49f CFC-recovery % CD44 CFC-recovery % CD133 CFC-recovery %
1 81 50 nil T3 7/N 10/12 30–100 92 (36/39) 9 (6/69) 2 (1/42)
2 72 478 nil T3 8/Y 6/6 80–100 89 (25/28) 30 (10/36) 0 (0/20)
3 73 55 AB T3 8/N 6/12 50–100 96 (25/26) 6 (2/35) 3 (1/40)
4 76 66 nil T3 9/N 11/12 30–90 86 (61/71) 28 (10/35) 0 (0/46)
5 68 92 nil T3 9/N 10/12 20–90 90 (52/58) * 6 (2/36)
Mean ±SD 74±5 148±185 90.6±3.7 18.3±12.5 2.2±2.5

All patients had Gleason score 7 or above, clinical stage T3, and one patient had metastatic disease at presentation. CFC-recovery (defined as the proportion of total CFCs within the positive fraction) was measured for each marker, with CD49f demonstrating the highest recovery.

AB = androgen ablation, SD = standard deviation.

*

sample infected.