Table 3. Association of concurrent conditions with GERD and chronic constipation and the adjusted–ratio.
| GERD (N = 142,086) | Constipation (N = 147,595) | ||||||
| Concurrent condition | Pre–index n (%) | Post–index n (%) | Odds Ratio (95% CI) | Pre–index n (%) | Post–index n (%) | Odds Ratio (95% CI) | Adjusted-ratio* (95% CI) |
| Anal Fissure | 277 (0.19) | 344 (0.24) | 1.24 (1.06–1.46) | 303 (0.21) | 921 (0.62) | 3.05 (2.68–3.48) | 2.46 (2.12–2.84) |
| Anal Fistula | 106 (0.07) | 139 (0.10) | 1.31 (1.02–1.69) | 96 (0.07) | 216 (0.15) | 2.25 (1.77–2.86) | 1.72 (1.37–2.15) |
| Ano–rectal hemorrhage | 2589 (1.82) | 5385 (3.79) | 2.12 (2.02–2.23) | 2469 (1.67) | 6928 (4.69) | 2.89 (2.76–3.03) | 1.36 (1.30–1.43) |
| Ano–rectal ulcers | 77 (0.05) | 151 (0.11) | 1.96 (1.49–2.58) | 50 (0.03) | 207 (0.14) | 4.14 (3.04–5.64) | 2.11 (1.66–2.69) |
| Crohn's disease | 412 (0.29) | 714 (0.50) | 1.74 (1.54–1.96) | 275 (0.19) | 456 (0.31) | 1.66 (1.43–1.93) | 0.96 (0.85–1.07) |
| Diverticular Disease | 3778 (2.66) | 9732 (6.85) | 2.69 (2.59–2.80) | 3241 (2.20) | 8752 (5.93) | 2.81 (2.69–2.92) | 1.04 (1.00–1.08) |
| Fecal Impaction | 351 (0.25) | 611 (0.43) | 1.74 (1.53–1.99) | 550 (0.37) | 3022 (2.05) | 5.59 (5.10–6.12) | 3.20 (2.83–3.62) |
| Fecal incontinence | 226 (0.16) | 334 (0.24) | 1.48 (1.25–1.75) | 369 (0.25) | 632 (0.43) | 1.72 (1.51–1.95) | 1.16 (0.99–1.35) |
| Hemorrhoids | 3942 (2.77) | 8770 (6.17) | 2.31 (2.22–2.40) | 4139 (2.80) | 11267 (7.63) | 2.86 (2.76–2.97) | 1.24 (1.20–1.30) |
| Hirschsprung's disease | 10 (0.01) | 10 (0.01) | 1.00 (0.42–2.40) | 12 (0.01) | 53 (0.04) | 4.42 (2.36–8.27) | 4.42 (2.46–7.92) |
| Irritable bowel syndrome | 2653 (1.87) | 5093 (3.58) | 1.95 (1.86–2.05) | 2394 (1.62) | 5162 (3.50) | 2.20 (2.09–2.31) | 1.12 (1.07–1.18) |
| Malignant neoplasm of colon | 504 (0.35) | 955 (0.67) | 1.90 (1.71–2.12) | 582 (0.39) | 1282 (0.87) | 2.21 (2.01–2.44) | 1.16 (1.05–1.30) |
| Rectal prolapse | 78 (0.05) | 111 (0.08) | 1.42 (1.07–1.90) | 124 (0.08) | 288 (0.20) | 2.33 (1.88–2.87) | 1.63 (1.27–2.10) |
| Ulcerative colitis | 419 (0.29) | 962 (0.68) | 2.30 (2.05–2.59) | 333 (0.23) | 662 (0.45) | 1.99 (1.75–2.27) | 0.86 (0.78–0.96) |
| Volvulus | 74 (0.05) | 180 (0.13) | 2.43 (1.86–3.19) | 81 (0.05) | 267 (0.18) | 3.30 (2.57–4.23) | 1.36 (1.07–1.72) |