Fig. 1.

Only BF, and not other drugs from the fibrate class, reduces C26:0 in X-ALD fibroblasts. (a) C26:0 levels in 3 X-ALD cell lines cultured for 7 days without drugs (black bar), in the presence of BF (gray bar), fenofibrate (white bar), or clofibrate (hatched bar). (b) C26:0 levels in 3 X-ALD cell lines cultured for 7 days without drugs (black bar), in the presence of BF (gray bar), agonists of PPAR-α (WY 14643), PPAR-β (GW 501516) and PPAR-γ (rosiglitazon), or with different combinations of PPAR agonists (white bars). (c) C26:0 levels in 8 control (white bar) and 8 X-ALD cell lines cultured without (black bar) or with 400 μM BF (gray bars) for up to 3 weeks. Fatty acid levels are in nmol/mg protein. Data are mean ± SD. * = p < 0.05, ** = P < 0.01, *** = P < 0.001 by ANOVA followed by Dunnett's multiple comparison test compared with untreated X-ALD cells