Figure 3.

Current/threshold slope. (A) Slope of the current/threshold relationship, recorded 200 ms after application of polarizing currents, and representing a threshold analogue of input conductance. Mean control recordings are in grey, and subjects with benign familial neonatal epilepsy are in black. (B) Distributions of slopes at the depolarizing end of the recording, as indicated by Arrow 1 in A. (C) Distributions of hyperpolarizing slopes, indicated by Arrow 2 in A. Subjects with benign familial neonatal epilepsy (BNFE) show less increase in conductance on depolarization, attributed to reduced activation of slow potassium channels, but no significant difference on hyperpolarization. **P < 0.01, NS = P > 0.05. NC = normal control.