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. Author manuscript; available in PMC: 2013 Oct 9.
Published in final edited form as: Curr Biol. 2012 Aug 2;22(19):1747–1754. doi: 10.1016/j.cub.2012.07.011

Figure 4. Scrib sensitizes cells to apoptosis and anoikis elicited by cell-cell contact.

Figure 4

(A) Dox treated control, βPIX-kd and βPIX+Scrib-kd cells were replated at high density and total cell lysates were immunoblotted to detect cleaved PARP. (B) The PARP signal from the representative experiment shown in (A) was quantified by densitometry and presented as a percent of the signal at the 12 h time point for βPIX-kd cells. (C) Distributions of 16 h suspension cultures labeled with FITC-VAD-FMK and analyzed by flow cytometry. (D) Percentages of “dead” FITC-VAD-FMK labeled populations from four independent experiments are reported as mean ± SD (* p<0.05; ** p<0.02). See also Figure S4.