Table 1. DAVID Functional Annotation Clustering & Enrichment Scores MPP+ (500μM) vs Control in N2a Cells @ 24 Hr.
Functional Annotation Clustering on statistically differentially genes between controls vs. MPP+ treated [500 μM] at 24 Hr.
| Category | Enrichment Score | Term | Average Count | P-Value |
|---|---|---|---|---|
| KP, GPF, SPK, USF | 9.96 | Glycolysis, glucose catabolic processes | 15 | 1.90E-16 |
| GPF, SPK, | 2.88 | Carboxylic Acid, Fatty Acid Metabolic Process | 11 | 9.80E-06 |
| GMF, SPK, UPF | 2.02 | ATP Binding | 31 | 3.50E-03 |
| SPK, USF | 2.02 | Phosphotransferases | 10 | 2.50E-05 |
| GMF, IP, SPK | 1.77 | Vit B6 Binding, Aminotransferase, Transaminase | 7 | 2.10E-03 |
| SMT, IP, GMF, SPK | 1.61 | Calponin-like actin binding, cytoskeleton | 8 | 6.90E-03 |
| GPF | 1.57 | Amino acid, biosynthetic process. serine, glycine, aspartate | 8 | 2.10E-03 |
| GPF | 1.55 | Carbohydrate biosynthesis, Pyruvate metabolic Process | 7 | 1.90E-02 |
| GCF | 1.45 | Melanosome | 5 | 2.20E-02 |
| SPK, USF, IP, GPF, GMF | 1.43 | NAD, NADH oxidation reduction | 16 | 5.30E-03 |
| SPK, CGF | 1.37 | Cytoskeletal, organization, intermediate filament | 7 | 5.20E-03 |
| SPK, GMF, GPF | 1.33 | Amino acid and carboxylic acid transporters | 5 | 2.40E-02 |
| SPK, GMF, SM, IP, USF | 1.32 | GTP Signaling | 12 | 5.70E-03 |
| GPF | 1.26 | Spinal Cord Development | 4 | 1.90E-02 |
| GPF | 1.11 | Cell Response to Unfolded proteins. ER stress | 3 | 1.80E-02 |
| SPK, GBF | 1.03 | Apoptosis | 12 | 2.50E-02 |
| GMF | 1.02 | GTPase activator activity | 8 | 1.00E-02 |
| SPK, GPF, | 0.96 | Cell Cycle | 13 | 7.60E-02 |
| GPF | 0.88 | Programmed Cell Death | 6 | 2.20E-02 |
| GPF, SPK, KP, USF | 0.84 | Mitochondria | 32 | 3.90E-04 |
| SPK, IP, GCF, GPF, USF | 0.67 | Angiogenesis | 5 | 8.30E-02 |
Category Abbreviations: GOTERM_BP_FAT (GPF), SP_PIR_KEYWORDS (SPK), Kegg Pathway (KP), UP_SEQ_FEATURE (USF). GOTERM_MF_FAT (GMF). GOTERM_CC_FAT (GCF), SMART (SM), INTERPRO (IP)
The data represent the database source (category), enrichment score, average # of genes affected in category (average count) and p-values (Fisher Exact/EASE Score).