Trial 1, 3-day treatment: Effects of doxazosin (1.25 – 5 mg/kg, IP) on alcohol intake (mean ±S.E.M). Doxazosin dose-dependently decreased alcohol intake, independent of day. Each bar represents data from 11-12 rats. ***p < .001 versus vehicle control treatment for 1.25, 2.5 and 5 mg/kg; a p < .01, 5 mg/kg versus 1.25 and 2.5 mg/kg. For significant differences between days, see text. Pre-treatment values reflect the averages from 5 daily sessions.