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(A) Amino acid sequence comparison of the human MCH-1R and MCH-2R. Identical residues are colored in red. Predicted transmembrane domains are indicated with a blue line. (B) Phylogenetic tree of the MCH neuropeptide receptor family including opioid, somatostatin, galanin, urotensin 2, and orphan receptors (GPR7, GPR8). (C) Exon/intron boarders of the human MCH-2R gene. Exon sequence is indicated by capital letters; intron sequence is noted in lowercase letters.
