Table 1.
Characteristics of the study population
| Characteristics | Total cases (N= 1651), N (%) |
Population-based cases (N = 1181), N (%) |
Clinic-based cases (N = 470), N (%) |
|---|---|---|---|
| Age at last follow-up, median (years) | 63 (range 23–93) | 65.0 (range 23–88) | 58 (range 28–93) |
| Sex | |||
| Female | 840 (51.9) | 595 (51.5) | 245 (52.9) |
| Male | 779 (48.1) | 561 (48.5) | 218 (47.1) |
| Missing | 32 (–) | 25 | 7 |
| Clinical criteria | |||
| Amsterdam I | 246 (15.0) | 114 (9.7) | 132 (29.0) |
| Amsterdam II | 306 (18.7) | 136 (11.5) | 170 (37.3) |
| Revised Bethesda guidelines | 1088 (65.9) | 681 (57.7) | 407 (86.6) |
| Pathogenic MMR gene mutations | |||
| Total | 239 (14.5) | 80 (6.8) | 159 (33.8) |
| MLH1 | 90 (5.4) | 27 (2.3) | 63 (13.4) |
| MSH2 | 125 (7.6) | 43 (3.6) | 82 (17.4) |
| MSH6 | 24 (1.5) | 10 (0.9) | 14 (3.0) |
MMR, mismatch repair.