Figure 9. NOD-derived BM-OCs are from pre-diabetic/euglycemic mice.
(A) Blood glucose was measured at time of sacrifice. C57Bl/6 (black circles, n=10), Balb/c (dark grey circles, n=10), NOR (light grey circles, n=19), NOD (white circles, n=23) (B) Pancreata from NOR (n=5) and NOD (n=5) were fixed, embedded, sectioned, H&E stained and scored using light microscopy based on percentage of lymphocyte infiltration (insulitis). no insulitis = black, peri-insulitis = hatched, intra-insulitis = white. (C) Representative sections of scoring technique. (i) no insulitis (ii) peri-insulitis (iii) intra-insulitis.