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. Author manuscript; available in PMC: 2012 Oct 14.
Published in final edited form as: Trends Immunol. 2011 Aug 11;32(10):452–460. doi: 10.1016/j.it.2011.06.008

Figure 3. Recruitment of neutrophils into a sterile necrotic site is mediated by a spatial cascade of chemoattractants.

Figure 3

(1) Necrotic tissues release DAMPs and ATP, which induce the release of IL-1β from resident tissue macrophages. (2) Secreted IL-1β induces the intravascular expression of ICAM-1, resulting in the adhesion of neutrophils to the endothelium surrounding the necrotic focus. Zones of chemoattractants are formed at different distances from the necrotic focus that sequential guide neutrophil migration into the lesion. (3) Farthest from the necrotic focus, a gradient of CXCR2 ligands is induced in the vasculature that guides neutrophils to the vicinity of the necrotic focus. (4) This chemokine gradient falls off close to the necrotic site, and neutrophils are then guided into the necrotic site by a gradient of FPRL1 ligands released from dying cells.