Table 1.
Major human and murine chemoattractants and their receptors expressed in neutrophils.
| Chemoattractant | Receptor | |||
|---|---|---|---|---|
| Chemokines | ||||
| Nomenclature | Receptors | |||
| Systemic | Human | Murine | Human neutrophils | Murine neutrophils |
| CXCL1 | GROα | KC | CXCR2 | CXCR2 |
| CXCL2 | GROβ | MIP-2 | CXCR2 | CXCR2 |
| CXCL3 | GROγ | n/a | CXCR2 | n/a |
| CXCL5 | ENA-78 | LIX | CXCR2 | CXCR2 |
| CXCL6 | GCP-2 | n/a | CXCR1/CXCR2 | n/a |
| CXCL7 | NAP-2 | NAP-2 | CXCR1/CXCR2 | CXCR2 |
| CXCL8 | IL-8 | n/a | CXCR1/CXCR2 | CXCR2 |
| CCL3 | MlP-lα | MIP-1α | n/a | CCR1 |
| CCL5 | RANTES | RANTES | n/a | CCR1 |
| CCL6 | (MPIF-1) | C10 | n/a | CCR1 |
| CCL7 | MCP-3 | MARC | n/a | CCR1 |
| CCL9 | (HCC-2) | MIP-1γ | n/a | CCR1 |
| CXCL12 | SDF-1α | SDF-1α | CXCR4 | CXCR4 |
| Peptides/Cytokines | |
|---|---|
| C5a | C5aR |
| C3a | C3aR |
| Formylated peptides (e.g. fMLF) | FPR1 |
| Pro-Gly-Pro (PGP) | CXCR2 |
| LL37 | FPR2 |
| MIF | CXCR2 |
| Eicosanoids | |
| Leukotriene B4 (LTB4) | BLT1 |
| Platelet activating factor (PAF) | PAFR |
Notes: The human and mouse chemokine system is not completely orthologous. For example, IL-8 and GCP-2 are not found in mice; MIP-1γ is not found in humans; CCR1 is not an important receptor on human neutrophils; and CXCR1 is not an important receptor on murine neutrophils. “n/a” stands for non-applicable. HCC-2 and MPIF-1 have also been given the systematic names CCL15 and CCL23, respectively [78].