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. Author manuscript; available in PMC: 2012 Oct 15.
Published in final edited form as: Methods. 2009 Aug 3;49(2):148–166. doi: 10.1016/j.ymeth.2009.07.005

Figure 10.

Figure 10

Both MA and MC coordinate the pro-SP nonbridging oxygen of the scissile phosphate. (A) Model showing potential metal ion-ligand interactions involving the pro-SP nonbridging oxygen (question marks). The grey sphere denotes a fourth divalent metal ion, a possibility not excluded from the results in (123). (B) Revised transition state model based on (124). Three metal ions are present in the active site, with metals A and C coordinating the pro-SP nonbridging oxygen of the scissile phosphate.