TABLE III.
Other Calcitriol (10−8 M) + DM and Paricalcitol (10−8 M) + DM Significantly Modulated Genes* Compared With DM
| Gene | Calcitriol fold change | Paricalcitol fold change | Gene function family |
|---|---|---|---|
| NLRP1 (3d) | +1.4 | +1.2 | Apoptosis |
| GIP3 (7d) | −1.8 | −1.7 | Cytokine |
| COL22A1 (3d) | +1.4 | +1.2 | Extracellular matrix |
| MAPK13 (3d) | +1.3 | +1.1 | Cell cycle/signal transduction |
| SLC22A3 (3d) | +2.1 | +1.8 | Cationic channel/transporter |
| GCLC (3d) | +1.4 | +1.2 | Anti-oxidant |
Affymetrix probe set numbers can be found in Supplemental data, Tables I and II.
NLRP1, NACHT-leucine-rich-repeat and PYD-(pyrin-domain)-containing-1; GIP3, interferon, alpha-inducible protein; COL22A1, collagen type 22, alpha 1; MAPK13, mitogen-activated-protein-kinase 13; SLC22A3, solute-carrier-family-22; GCLC, glutamate-cysteine ligase, catalytic subunit.
*
Values are at the measurement of maximal change (4 h, 1, 3, or 7 days) for calcitriol (10−8 M) + DM. Bold: P < 0.001.