ABO blood groups in patients with malaria. (A) ABO groups according to the spectrum of disease severity. Controls have a higher prevalence of group O, and cases have a higher prevalence of non-group O. (B) ABO distributions among the cases (severe or fatal malaria) are significantly different from that observed in healthy adult Ugandan blood donors. (C) Among group A or AB cases, A1 positive cases are more likely to have CM or LA than those negative for A1. UM-o, uncomplicated malaria treated as an outpatient; UM-i, uncomplicated malaria treated as an inpatient. SM-s, severe malaria, survivor; SM-f, severe malaria, fatal; SMA, severe malaria anaemia; LA, lactic acidosis; CM, cerebral malaria.