Table 1.
Clinical characteristics of patients
| Baseline characteristics | All | MBL ≤500 ng/mL | MBL >500 ng/mL | P-value |
|---|---|---|---|---|
| |
(n = 246) |
(n = 57) |
(n = 189) |
|
| Age in years, mean (SD) |
75 (9.4) |
74 (10.5) |
75 (9.5) |
0.4 |
| Female sex, n (%) |
89 (36) |
24 (42) |
65 (34) |
0.4 |
| MBL in ng/mL, median (IQR) |
2150 (560–3794) |
127 (11–330) |
2855 (1701–4347) |
n/a |
| BMI in kg/m2, median (IQR) |
26 (23–29) |
27 (24–30) |
26 (23–29) |
0.09 |
| Contrast medium in mL, median (IQR) |
100 (80–160) |
100 (80–150) |
100 (80–170) |
0.3 |
| Medical history |
|
|
|
|
| Hypertension, n (%) |
204 (83) |
48 (84) |
156 (83) |
0.8 |
| D.m., n (%) |
90 (37) |
19 (33) |
71 (38) |
0.6 |
| Dyslipidemia, n (%) |
145 (59) |
34 (60) |
111 (59) |
1.00 |
| Coronary heart disease, n (%) |
143 (58) |
31 (54) |
112 (59) |
0.5 |
| CHF, n (%) |
111 (45) |
23 (40) |
88 (47) |
0.5 |
| Peripheral artery disease, n (%) |
64 (26) |
11(19) |
53 (28) |
0.2 |
| Current smoking, n (%) |
40 (16) |
7 (12) |
33 (17) |
0.4 |
| Medication |
|
|
|
|
| ACE-Inhibitor, n (%) |
108 (44) |
23 (40) |
85 (45) |
0.7 |
| AT-II-Inhibitor, n (%) |
69 (28) |
13 (23) |
56 (30) |
0.40 |
| Diuretics, n (%) |
173 (70) |
41 (72) |
132 (70) |
0.9 |
| NSAIDs, n (%) |
8 (3) |
5 (9) |
3 (2) |
0.02 |
| Baseline parameters |
|
|
|
|
| Systolic BP in mmHg, median (IQR) |
130 (120–146) |
132 (120–149) |
130 (117–145) |
0.1 |
| Diastolic BP in mmHg, median (IQR) |
70 (60–80) |
76 (65–80) |
70 (60–80) |
0.01 |
| Creatinine in μmol/L, median (IQR) |
137 (114–162) |
140 (113–154) |
136 (114–164) |
0.9 |
| Cystatin C in mg/L, median (IQR) |
1.7 (1.5-2.0) |
1.8 (1.5-2.0) |
1.7 (1.5-2.1) |
0.8 |
| eGFR in mL/min/1.73 m2, median (IQR) |
44 (35–52) |
44 (35–51) |
44 (35–53) |
0.8 |
| Type of procedure |
|
|
|
|
| Coronary angiogram, n (%) |
110 (45) |
23 (40) |
87 (46) |
0.5 |
| PCI, n (%) |
52 (21) |
12 (21) |
40 (21) |
1.00 |
| CT scan, n (%) |
110 (45) |
29 (51) |
81 (43) |
0.3 |
| Other, n (%) |
26 (11) |
5 (9) |
21 (11) |
0.8 |
| Intervention group |
|
|
|
|
| Standard 24 h sodium chloride, n (%) |
85 (35) |
16 (28) |
69 (37) |
0.3 |
| 7 h sodium bicarbonate, n (%) |
82 (33) |
22 (39) |
60 (32) |
0.3 |
| Short-term sodium bicarbonate, n (%) | 79 (32) | 19 (33) | 60 (32) | 0.9 |
P-values are given for the difference between MBL ≤500 and >500 ng/ml. Abbreviations: D.m. = Diabetes mellitus; IQR = interquartile range; BMI = body mass index; CHF = congestive heart failure class I/II by New York Heart Association classification; NSAIDs = non-steroidal anti-inflammatory drugs; eGFR = estimated glomerular filtration rate; CT scan = computer tomography scan. PCI = percutaneous coronary intervention; BP = blood pressure; SD = standard deviation.