Table 2.
Changes in hemodynamic, arterial stiffness and metabolic parameters in metformin treated patients during 12 months follow up
| Variable |
Metformin treated patients |
||||
|---|---|---|---|---|---|
| Baseline | 4 month | p-valueV1 vs V2 | 12 month | p-valueV1 vs V3 | |
| Systolic BP (mm/Hg) |
139.0 ± 17.9 |
137.2 ± 20.1 |
0.565 |
131.5 ± 14.0 |
0.060 |
| Diastolic BP (mm/Hg) |
80.6 ± 9.2 |
78.4 ± 9.0 |
0.403 |
80.9 ± 8.8 |
0.921 |
| Aortic AP (mm/Hg) |
15.6 ± 9.1 |
11.4 ± 7.6 |
0.001 |
12.8 ± 5.2 |
0.257 |
| AI (%) |
31.4 ± 10.2 |
23.1 ± 8.5 |
<0.0001 |
24.8 ± 7.9 |
0.009 |
| Total Cholesterol (mg/dl) |
179.3 ± 40.3 |
176.7 ± 32.2 |
0.722 |
178.2 ± 25 |
0.985 |
| Triglycerides (mg/dl) |
195.4 ± 119.1 |
157.9 ± 97.4 |
0.033 |
195.7 ± 149.7 |
0.574 |
| HDL-cholesterol (mg/dl) |
41.3 ± 12.2 |
45.7 ± 15.0 |
0.001 |
42.2 ± 11.6 |
0.768 |
| LDL Cholesterol (mg/dl) |
103.5 ± 37.3 |
103.7 ± 22.1 |
0.979 |
111.8 ± 23.8 |
0.286 |
| ALP (U/l) |
66.5 ± 17.8 |
61.1 ± 15.6 |
0.007 |
65.2 ± 19.7 |
0.452 |
| ALT (U/l) |
38.5 ± 31.7 |
29.3 ± 16.2 |
0.092 |
39.2 ± 21.8 |
0.838 |
| AST (U/l) |
29.0 ± 18.0 |
25.4 ± 9.7 |
0.300 |
30.6 ± 11.6 |
0.991 |
| hs-CRP (mg/dl) |
1.0 ± 1.1 |
0.5 ± 0.4 |
0.081 |
0.7 ± 0.9 |
0.448 |
| Fasting glucose (mg/dl) |
135.0 ± 52.8 |
115.8 ± 27.0 |
0.036 |
125.7 ± 54 |
0.185 |
| Adiponectin (ng/ml) |
5661.8 ± 2820 |
6166.6 ± 3265 |
0.171 |
6102.4 ± 2139 |
0.746 |
| HOMA-IR | 7.2 ± 6.3 | 7.3 ± 10.9 | 0.920 | 5.7 ± 6 | 0.042 |