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GAP43 immunohistochemical staining of the infarct border zone (DAB color, ×200). (a) Sham-operated group. The distribution of GAP43-positive nerve fibers is orderly. (b) Control ischemic group. GAP43-positive nerve fibers in ventricular muscle increased significantly, it is also thickened and disordered. (c) Preischemic treatment group. (d) Delayed application group. The distribution of GAP43-positive nerve fibers after treatment with desipramine significantly improved.
