Table 1.
Demographic data and the prevalence of pre-S mutations associated with progressive liver disease
| AC | CH | LC | HCC | All | P value (all) | P value (AC-CH vs LC) | P value (AC-CH vs HCC) | |
| n (%) | 73 (27.2) | 66 (24.6) | 66 (24.6) | 63 (23.5) | 268 (100.0) | - | - | - |
| Gender, n (%) | ||||||||
| Male | 69 (94.5) | 49 (74.2) | 46 (69.7) | 49 (77.7) | 213 (79.5) | 0.002 | 0.027 | 0.314 |
| Female | 4 (5.5) | 17 (25.8) | 20 (30.3) | 14 (22.2) | 55 (20.5) | |||
| Age (yr, mean ± SD) | 32.3 ± 9.1 | 41.9 ± 13.3 | 50.1 ± 10.9 | 48.6 ± 11.6 | 42.9 ± 13.3 | < 0.001 | < 0.001 | < 0.001 |
| Genotype, n (%) | ||||||||
| B | 56 (76.7) | 46 (69.7) | 46 (69.7) | 52 (82.5) | 200 (74.6) | 0.267 | 0.453 | 0.393 |
| C | 17 (23.3) | 20 (30.3) | 20 (30.3) | 11 (17.5) | 68 (25.4) | |||
| HBeAg1 | ||||||||
| HBeAg(+) | 13 (22.0) | 36 (56.3) | 18 (30.5) | 15 (28.3) | 82 (34.9) | < 0.001 | 0.222 | 0.144 |
| HBeAg(-) | 46 (78.0) | 28 (43.8) | 41 (69.5) | 38 (71.7) | 153 (65.1) | |||
| Mutation | ||||||||
| M120 | 2 (2.7) | 12 (18.2) | 27 (40.9) | 18 (28.6) | 59 (22.0) | < 0.001 | < 0.001 | 0.002 |
| T130 | 8 (11.0) | 19 (28.8) | 18 (27.3) | 25 (39.7) | 70 (26.1) | 0.0018 | 0.311 | 0.054 |
| Q132 | 11 (15.1) | 19 (28.8) | 21 (31.8) | 26 (41.3) | 77 (28.7) | 0.008 | 0.111 | 0.04 |
| A138 | 10 (13.7) | 21 (31.8) | 22 (33.3) | 26 (41.3) | 79 (29.5) | 0.003 | 0.089 | 0.094 |
1
Number of samples for HBeAg. n (all) = 235, n (AC:CH:LC:HCC) = 59:64:59:53. AC: Asymptomatic carrier; CH: Chronic hepatitis; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; HBeAg: Hepatitis B e antigen.