Table 2.

Pre-S mutation as risk factor for progressive liver disease adjusted with age, sex, and hepatitis B e antigen (n = 235)

	P-value	OR (95% CI)	P-value	OR adjusted (95% CI)
AC-CH vs LC-HCC
Age, mean ± SD	1.99E-11	1.099 (1.069-1.130)
Gender (male)	0.049	0.531 (0.281-1.002)
HBeAg(-)	0.096	1.585 (0.921-2.730)
Mutation
M120	3.23E-06	4.942 (2.427-10.064)	0.0005	3.996 (1.830-8.729)
T130	0.078	1.684 (0.940-3.016)	0.531	1.246 (0.626-2.483)
Q132	0.029	1.885 (1.064-3.339)	0.352	1.379 (0.701-2.712)
A138	0.041	1.801 (1.020-3.178)	0.580	1.209 (0.617-2.370)
AC-CH vs LC
Age, mean ± SD	8.86E-09	1.096 (1.063-1.131)
Gender (male)	0.027	0.442 (0.213-0.920)
HBeAg(-)	0.222	1.508 (0.778-2.922)
Mutation
M120	9.50E-07	6.343 (2.878-13.980)	4.00E-05	6.406 (2.640-15.540)
T130	0.311	1.440 (0.710-2.918)	0.672	1.198 (0.518-2.770)
Q132	0.111	1.740 (0.878-3.449)	0.364	1.457 (0.646-3.287)
A138	0.089	1.791 (0.911-3.523)	0.485	1.330 (0.597-2.964)
AC-CH vs HCC
Age, mean ± SD	2.13E-07	1.084 (1.052-1.118)
Gender (male)	0.314	0.663 (0.298-1.479)
HBeAg(-)	0.144	1.677 (0.835-3.372)
Mutation
M120	0.002	3.651 (1.570-8.490)	0.052	2.538 (0.992-6.494)
T130	0.054	1.987 (0.981-4.022)	0.402	1.413 (0.629-3.174)
Q132	0.041	2.056 (1.024-4.129)	0.498	1.321 (0.590-2.953)
A138	0.094	1.811 (0.900-3.644)	0.744	1.144 (0.509-2.571)

AC: Asymptomatic carrier; CH: Chronic hepatitis; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; CI: Confidence interval; OR: Odds ratio; HBeAg: Hepatitis B e antigen.