Table 5.

Prevalence of pre-S mutations in hepatitis B e antigen (-) and hepatitis B e antigen (+) associated with progressive liver disease

Mutation	HBeAg(-)						HBeAg(+)
	AC	CH	LC	HCC	All	P-value	AC	CH	LC	HCC	All	P-value
	n = 46	n = 28	n = 41	n = 38	n = 155		n = 13	n = 36	n = 18	n = 15	n = 82
M12	0 (0.0)	10 (35.7)	17 (41.5)	9 (23.7)	36 (23.5)	< 0.001	0 (0.0)	2 (5.6)	7 (38.9)	6 (40.0)	15 (18.3)	< 0.001
T130	6 (13.0)	10 (35.7)	11 (26.8)	13 (34.2)	40 (26.1)	0.082	2 (15.4)	9 (25.0)	6 (33.3)	6 (40.0)	23 (28.0)	0.474
Q13	6 (13.0)	10 (35.7)	12 (29.3)	14 (36.8)	42 (27.5)	0.057	3 (23.1)	9 (25.0)	8 (44.4)	6 (40.0)	26 (31.7)	0.389
A13	6 (13.0)	10 (35.7)	13 (31.7)	13 (34.2)	42 (27.5)	0.072	2 (15.4)	11 (30.6)	8 (44.4)	6 (40.0)	27 (32.9)	0.344

AC: Asymptomatic carrier; CH: Chronic hepatitis; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; HBeAg: Hepatitis B e antigen.