Table 2.
Comparisons of regeneration and necrosis in young and old mdx mice
| Vectors | n | Age at vector injection | Months post injection | % of regenerative fibers * | % of necro-fibers* |
|---|---|---|---|---|---|
| PBS | 4 | 1 month | 1 month | 30.8 (460/1495) | 25.6 (349/1363) |
| IKKα-dn | 4 | 1 | 1 | 29.9 (556/1859) | 19.7 (265/1343) |
| IKKα-wt | 4 | 1 | 1 | 28.4 (450/1584) | 25.2 (371/1471) |
| IKKβ-dn | 4 | 1 | 1 | 29.3 (319/1087) | 17.0 (184/1081) |
| IKKβ-wt | 4 | 1 | 1 | 27.1 (431/1593) | 22.5 (318/1412) |
|
| |||||
| PBS | 4 | 2 | 1 | 19.6 (300/1532) | 24.8 (280/1129) |
| IKKα-dn | 4 | 2 | 1 | 20.5 (421/2058) | 14.8 (120/810) |
| IKKα-wt | 4 | 2 | 1 | 18.6 (362/1948) | 26.7 (379/1420) |
| IKKβ-dn | 4 | 2 | 1 | 20.2 (310/1534) | 13.1 (146/1116) |
| IKKβ-wt | 4 | 2 | 1 | 22.5 (229/1017) | 23.2 (254/1094) |
|
| |||||
| PBS | 4 | 11 | 1 | 1.4 (20/1401) | 34.0 (437/1284) |
| IKKα-dn | 4 | 11 | 1 | 4.3 (87/2026) | 15.5 (339/2186) |
| IKKα-wt | 4 | 11 | 1 | 0.8 (9/1095) | 35.4 (394/1113) |
| IKKβ-dn | 4 | 11 | 1 | 9.8 (118/1203) | 15.3 (312/2033) |
| IKKβ-wt | 4 | 11 | 1 | 0.9 (12/1399) | 34.4 (521/1514) |
*
Percentage: positive IF staining vs all numbers in visible area including both negative and positive myofibers in gastrocnemius (GAS) and tibialis anterior (TA) muscles.