Table 1.
Summary of pro- and antiangiogenic factors involved in corneal NV
| Proangiogenic Factors | Antiangiogenic Factors |
|---|---|
| Vascular endothelial growth factors • VEGF-A, VEGF-C, etc. |
Vascular endothelial growth factor receptors • sVEGFR1, mVEGFR3, etc. |
|
| |
| Fibroblast growth factors • FGF1, FGF2 (bFGF), etc. |
Pigment epithelium-derived factor |
|
| |
| Platelet-derived growth factors • PDGF-AA, PDGF-AB, etc. |
Collagen derivatives • Endostatin, canstatin, etc. |
|
| |
| Angiopoietins • Ang-1, (±) Ang-2 |
Angiopoietins • Ang-2 |
|
| |
| Angiogenin | Angiostatin |
|
| |
| Matrix metalloproteinases • MT-1MMP, MMP-2, etc. |
Matrix metalloproteinases • Epithelial MT1-MMP, MMP- 7, etc. |
|
| |
| Integrins • αVβ3, α1β1, etc. |
Tissue inhibitors of matrix metalloproteinases • TIMP-1, TIMP-2, etc. |
|
| |
| Cytokines/chemokines • IL-1, IL-8/CXCL8, etc. |
Cytokines/chemokines • IL-1RA, IP-10/CXCL10, etc. |
|
| |
| Hepatocyte growth factor/scatter factor |
Thrombospondins and CD36 • TSP-1, TSP-2, etc. |
|
| |
| Insulin-like growth factor | Death signaling pathways • Fas/FasL, CD80/PD-L1 |
|
| |
| Renin-angiotensin system |
Decorin, small leucine-rich proteoglycan |
|
| |
| Placental growth factor | Placental growth factor |
|
| |
| Leptin | Prolactin |
|
| |
| Thrombin | Anti-thrombin |
|
| |
| Platelet activating factor | Plasminogen activator inhibitor |