Grouped adverse events | Specific adverse events | Both phases (N=53)* |
% | Intensive phase (N=53) |
% | Continuation phase (N=49)† |
% |
Hearing loss & Tinnitus | Tinnitus | 24 | 45% | 21 | 40% | 3 | 6% |
Decreased hearing | 13 | 25% | 12 | 23% | 1 | 2% | |
Hearing loss & Tinnitus Total | 37 | 70% | 33 | 62% | 4 | 8% | |
GIT-related | Nausea | 12 | 23% | 8 | 15% | 4 | 8% |
Abdominal pain | 9 | 17% | 8 | 15% | 1 | 2% | |
Vomiting | 6 | 11% | 6 | 11% | 0 | 0% | |
Diarrhea | 5 | 9% | 5 | 9% | 0 | 0% | |
Constipation | 2 | 4% | 2 | 4% | 0 | 0% | |
GIT Total | 34 | 64% | 29 | 55% | 5 | 10% | |
Others | Joint pain | 15 | 28% | 13 | 25% | 2 | 4% |
Headache | 11 | 21% | 10 | 19% | 1 | 2% | |
Fatigue | 10 | 19% | 8 | 15% | 2 | 4% | |
Dizziness | 8 | 15% | 7 | 13% | 1 | 2% | |
Rash | 7 | 13% | 7 | 13% | 0 | 0% | |
Neuropathy | 4 | 8% | 2 | 4% | 2 | 4% | |
Fever | 3 | 6% | 3 | 6% | 0 | 0% | |
Vision changes | 3 | 6% | 2 | 4% | 1 | 2% | |
Depression | 2 | 4% | 2 | 4% | 0 | 0% | |
Psychosis | 2 | 4% | 2 | 4% | 0 | 0% | |
Severe hepatitis | 1 | 2% | 1 | 2% | 0 | 0% | |
Decreased urine | 1 | 2% | 1 | 2% | 0 | 0% | |
Anemia | 2 | 4% | 2 | 4% | 0 | 0% | |
Loss of libido, delayed ejaculation | 1 | 2% | 0 | 0% | 1 | 2% | |
Total of all adverse events | 141 | 122 | 19 | ||||
Percent of all adverse events | 100% | 87% | 13% |
* 53 of the 59 patients reported to have experienced at least one DR-TB treatment-related adverse event. All the 53 patients had either completed or were still in the intensive phase of treatment at the time of data collection.
† 49 of the patients had progressed into the continuation phase of treatment and were either still on continuation phase treatment or had completed treatment at the time of data collection.
%= percent. Sum of column percentages may exceed 100% because a patient may experience more than one adverse event. GIT = gastrointestinal tract