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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Cell Biochem. 2012 Sep;113(9):2813–2821. doi: 10.1002/jcb.24178

Fig. 2.

Fig. 2

The LINC complex. The LINC complex is composed of two protein types: a KASH-domain protein (light green), which spans the ONM, and a SUN-domain protein (dark green), which spans the INM. The KASH and SUN domain proteins interact in the NE lumen via their respective domains (striated regions). KASH-domain proteins interact in the cytoplasm with elements of the cytoskeleton (red), such as microtubules and actin cable. SUN-domain proteins interact in the nucleoplasm with the nuclear lamina (brown mesh-work).