. Author manuscript; available in PMC: 2012 Oct 15.

Published in final edited form as: Pharmacol Rev. 2006 Sep;58(3):281–341. doi: 10.1124/pr.58.3.3

TABLE 1.

Accepted human P2Y receptors

Receptor	Chromosome (Human)	Agonist (Human)	Phenotype of Knockout Mice
P2Y₁	3q24–25	ADP	Inhibition of platelet aggregation
			Increased bleeding time
			Resistance to thromboembolism
P2Y₂	11q13.5	ATP = UTP	Abolition of chloride secretory response to ATP/UTP in airways
P2Y₄	Xq13	UTP	Abolition of chloride secretory response to ATP/UTP in jejunum and colon
P2Y₆	11q13.5	UDP	No knockout mice are available
P2Y₁₁	19p31	ATP	No murine P2Y₁₁ gene
P2Y₁₂	3q21–25	ADP	Inhibition of platelet aggregation
			Increased bleeding time
			Resistance to thromboembolism
P2Y₁₃	3q24–25	ADP	Available, no phenotype yet
P2Y₁₄	3q24–25	UDP-glucose	No knockout mice are available