Figure 2.
A comparison of the p-values of the most-perturbed sub-pathways computed by ActiveModules to those computed by our algorithm. Each point represents a pathway-cancer pair: the x-axis is the p-value of the most-perturbed sub-pathway computed by our algorithm, while the y-axis is the p-value of the most-perturbed pathway, as computed by ActiveModules. The x = y line is shown in dashed green. (a) Data for all pathway-cancer pairs. (b) Data restricted to pathway-cancer pairs where the most perturbed sub-pathway computed by our algorithm has a p-value at most 0.05.