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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Immunol Rev. 2012 Nov;250(1):167–179. doi: 10.1111/j.1600-065X.2012.01166.x

Fig. 4. Docking modes of NKT and MHC-reactive TCRs.

Fig. 4

Role of CDR3α (blue) and CDR3β (red) in binding to CD1 (grey), MHC I (light blue), and antigen (yellow). (A). Type I NKT TCR docking to CD1d presenting αGalCer (PDB ID 3HE6). (B). Type II NKT TCR docking to CD1d presenting lysosulfatide (PDB ID 3ELM). (C). MHC-reactive TCR docking to H-2Kb –peptide (PDB ID 2CKB). The lines show the direction of the vector connecting the centroids of the conserved V domain disulfide bonds.