Table 1.

List of human NK cell receptors: structures, signaling, and viral involvement.

activating receptor	PDB	ligand	signaling	virus	references
NKG2D	1HQ8, 1HYR (NKG2D/MICA), 1KCG (NKG2D/ULBP3), 1JSK (NKG2D/Rae-1β)	MICA/B, ULBP1-6	DAP10	HCMV, KSV, HBV, HIV- 1, IV	126, 128, 129, 162–165
NKG2C- CD94	2L35 (DAP12/NKG2C)	HLA-E	DAP12	HCMV, HBV, HCV, hantavirus	112, 120, 122, 142, 166, 167,
NKp46 (NCR1)	1P6F, 1OLL	HA, heparan sulfate/ heparin	FcεRIγ, CD3ζ	Influenza, vaccinia, HCV, HSV, NDV, SeV	14, 139–143, 146–148, 153
NKp44 (NCR2)	1HKF	HA, heparan sulfate/ heparin, E- protein, PCNA, bacterial cell wall elements	DAP12	Influenza, vaccinia, HSV, NDV, SeV, Dengue, West Nile, HIV-1	138, 139, 143, 146, 149, 153, 168
NKp30 (NCR3)	3NOI	B7H6, BAT3, HCMV pp65, heparan sulfate/hep arin, PfEMP-1	FcεRIγ, CD3ζ	Influenza, vaccinia, HCV, HSV, HCMV, Ebola, Marburg	140, 142–144, 146, 150–154, 169, 170
NKp80	---	Activation- induced C- type lectin	AICL	KSV	163, 171
KIR2DS1	---	HLA- Cw2,4,5,6 (C2 epitope)	DAP12	EBV	15
KIR2DS2	1M4K	---	DAP12	HCV, HSV-1	172, 173
KIR2DS4	3H8N	HLA-Cw4	DAP12	HCV	174–176
KIR3DS1	---	HLA-Bw4?	DAP12	HIV	42, 44, 49
KIR2DL4	3H8N	HLA-G	FceRIg, 1 ITIM		177
inhibitory receptor	structure	ligand	signaling	virus	references
NKG2A/B- CD94	1B6E (CD94), 3BDW (CD94/NKG2A), 3CDG and 3CII (CD94/NKG2A/H LA-E)	HLA-E	1 ITIM	HCMV, HIV-1, HCV	88, 107, 112, 123, 178, 179, 180
KIR2DL1	1NKR, 1IM9 (KIR2DL1/HLA- Cw4)	HLA- Cw2,4,5,6 (C2 epitope)	2 ITIM	EBV	15, 60, 181
KIR2DL2	2DL1, 2DL2, 1EFX (KIR2DL2/HLA- Cw3)	HLA- Cw1,3,7,8 (C1 epitope)	2 ITIM	HCV, HSV-1	61, 172, 182, 183
KIR2DL3	1B6U	HLA- Cw1,3,7,8 (C1 epitope)	2 ITIM	HCV	184, 36
KIR3DL1	3VH8	HLA-A, B (Bw4 epitope)	2 ITIM	HIV	49, 63, 185
LILRB1 (ILT2)	1UFU, 1VDJ, 1G0X, 1P7Q (LIR1/HLA-A2), 3D2U (LIR1/UL18)	HLA class I, HLA-G, HLA-F, HLA-E, UL18	4 ITIM	HCMV, HIV-1	75, 84, 85, 95
LILRB2 (ILT4)	2GW5, 2DYP (LIR2/HLA-G)	HLA class I, HLA-G, HLA-F, HLA-E, UL18	3 ITIM	HCMV, HIV-1	75, 96, 99