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. 2012 Jul 30;21(21):4793–4804. doi: 10.1093/hmg/dds302

Figure 3.

Figure 3.

The box plot shows TPMT activity in 286 patients with ALL as a function of the TPMT rs1142345 [A719G]/PACSIN2 rs2413739 multilocus genotype. There were no GG genotypes for TPMT rs1142345 and therefore all variants genotypes for TPMT are heterozygous. SNPs in both genes had a significant association with TPMT enzyme activity in a univariate analysis (P-values from linear model with formula TPMT activity–genotype, considering an additive effect for the genotype: TPMT = 6.0 × 10−16; PACSIN2 P = 0.027). Moreover, these SNPs (TPMT, PACSIN2) were also significantly related to TPMT activity in a multivariate analysis that combined the two SNPs in a multilocus genotype (TPMT P-value from linear model = 3.0 × 10−16 and PACSIN2 P-value from linear model = 0.011). The PACSIN2 genotype had a significant effect even in the subgroup with the wild-type TPMT genotype (P-value from linear model = 0.031) and in the subgroup with the variant TPMT genotype (P-value from linear model = 0.0091).