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The frequency of severe (Grade 3–4) GI toxicity during consolidation therapy in the validation cohort, the Italian AIEOP-BFM-ALL 2000 and genotypes in PACSIN2; PACSIN2 SNP rs2413739 and rs737782 resulted associated with the incidence of GI toxicity in this cohort (P-values from logistic regression model, 0.032 and 0.015, respectively).
