Table 1.
Genes whose expression was statistically associated with TPMT activity (P-value lower than 5 × 10−5) in 87 Human HapMap CEU cell lines
| Transcript ID | Chromosome | Gene ID | Gene symbol | Reference sequence | Correlation estimate | P-value |
|---|---|---|---|---|---|---|
| 3764471 | chr17 | 9110 | MTMR4 | NM_004687 | 0.55 | 1.48E−07 |
| 3454006 | chr12 | 91010 | FMNL3 | NM_198900, NM_175736 | 0.52 | 5.27E−07 |
| 3496409 | chr13 | 2262 | GPC5 | NM_004466 | 0.48 | 6.91E−07 |
| 3290785 | chr10 | 8030 | CCDC6 | NM_005436 | 0.49 | 1.07E−06 |
| 3456212 | chr12 | 7786 | MAP3K12 | NM_006301 | 0.47 | 1.35E−06 |
| 3403595 | chr12 | 50856 | CLEC4A | NM_016184,NM_194450,NM_194447, NM_194448 | 0.39 | 1.85E−06 |
| 3275729 | chr10 | 3559 | IL2RA | NM_000417 | 0.44 | 2.46E−06 |
| 3662417 | chr16 | 1071 | CETP | NM_000078 | 0.39 | 2.91E−06 |
| 3832256 | chr19 | 10653 | SPINT2 | NM_021102 | 0.44 | 3.20E−06 |
| 3063795 | chr7 | 55262 | C7orf43 | NM_018275 | 0.46 | 5.96E−06 |
| 3156307 | chr8 | 5747 | PTK2 | NM_005607,NM_153831 | 0.43 | 6.57E−06 |
| 3883819 | chr20 | 22839 | DLGAP4 | NM_183006,NM_001042486,NM_014902 | 0.40 | 7.88E−06 |
| 3338968 | chr11 | 55191 | NADSYN1 | NM_018161 | 0.46 | 1.08E−05 |
| 3426257 | chr12 | 8835 | SOCS2 | NM_003877 | 0.44 | 1.11E−05 |
| 3962678 | chr22 | 11252 | PACSIN2 | NM_007229 | 0.38 | 1.20E−05 |
| 3965784 | chr22 | 5600 | MAPK11 | NM_002751 | 0.37 | 1.42E−05 |
| 3621080 | chr15 | 9333 | TGM5 | NM_201631, NM_004245 | 0.34 | 1.44E−05 |
| 3608638 | chr15 | 9899 | SV2B | NM_014848 | 0.39 | 1.47E−05 |
| 3802980 | chr18 | 1824 | DSC2 | NM_004949, NM_024422 | 0.41 | 1.50E−05 |
| 3470193 | chr12 | 1240 | CMKLR1 | NM_004072 | 0.40 | 1.53E−05 |
| 3479438 | chr12 | 55743 | CHFR | NM_018223 | 0.49 | 1.69E−05 |
| 2803329 | chr5 | 10409 | BASP1 | NM_006317 | 0.47 | 1.78E−05 |
| 3362263 | chr11 | 23258 | RAB6IP1 | NM_015213 | 0.45 | 2.27E−05 |
| 3830484 | chr19 | 2867 | FFAR2 | NM_005306 | 0.35 | 2.32E−05 |
| 2766492 | chr4 | 201895 | C4orf34 | NM_174921 | 0.39 | 2.72E−05 |
| 3476097 | chr12 | 8099 | CDK2AP1 | NM_004642 | 0.40 | 2.85E−05 |
| 3833793 | chr19 | 53916 | RAB4B | NM_016154 | 0.45 | 3.14E−05 |
| 3405032 | chr12 | 2120 | ETV6 | NM_001987 | 0.50 | 3.23E−05 |
| 3240987 | chr10 | 1326 | MAP3K8 | NM_005204 | 0.48 | 3.25E−05 |
| 2412312 | chr1 | 22996 | C1orf34 | NM_001080494 | 0.41 | 3.52E−05 |
| 3802924 | chr18 | 1825 | DSC3 | NM_001941, NM_024423 | 0.38 | 3.65E−05 |
| 2485688 | chr2 | 23177 | CEP68 | NM_015147 | 0.39 | 3.77E−05 |
| 3662612 | chr16 | 89970 | RSPRY1 | NM_133368 | 0.48 | 3.82E−05 |
| 2556752 | chr2 | 200734 | SPRED2 | NM_181784 | 0.47 | 3.84E−05 |
| 3753860 | chr17 | 256957 | C17orf66 | NM_152781 | 0.31 | 4.31E−05 |
| 2500275 | chr2 | 10018 | BCL2L11 | NM_138621, NM_006538 | -0.40 | 4.47E−05 |
| 3470597 | chr12 | 54434 | SSH1 | NM_018984 | 0.38 | 4.66E−05 |
| 3338192 | chr11 | 595 | CCND1 | NM_053056 | 0.36 | 4.72E−05 |
P-values are from linear mixed effects model with formula: log2(TPMT activity) ∼ gene expression, adjusted for relatedness.