Table 2.
Multivariate logistic regression model for the effects of PACSIN2, SLCO1B1 and TPMT genotypes on the incidence of GI toxicity
| Multivariate logistic regression model for the incidence of GI toxicity |
Multivariate logistic regression model for the incidence of GI toxicity, adjusted for ethnicitya |
|||||
|---|---|---|---|---|---|---|
| Effectb | 95% Confidence interval | P-value | Effectb | 95% Confidence interval | P-value | |
| PACSIN2 rs2413739 genotype (T versus C) | 2.06 | 1.01–4.56 | 0.040 | 2.09 | 1.03–4.58 | 0.037 |
| SLCO1B1 rs11045879 genotype (T versus C) | 12.61 | 1.69–1613.81 | 0.017 | 11.49 | 1.56–1466.31 | 0.0016 |
| TPMT rs1142345 genotype (A versus G) | 6.03 | 1.23–27.26 | 0.0085 | 6.58 | 1.11–33.33 | 0.045 |
aEthnicity was defined by self-reported race (white for 143 patients, black for 37 patients, Asian for 1 patient and other for 8 patients).
bThe coefficient or effect size represents the odds ratio for toxicity associated with each variable listed. For example, a patient with a G allele for TPMT rs1142345 would have an odd ratio toxicity of 6.03 in comparison with a patient with the A allele.