Table 4.
Enrichment analysis of mRNA differentially expressed in human NALM6 leukemia cells, between PACSIN2 controls and knock-down
| MetaCore GeneGo | Ranking | Pathway name | P-value | Ratio probe sets significant/in pathway | Significant mRNAs in pathway |
|---|---|---|---|---|---|
| GeneGo pathway maps | #1 | wtCFTR and delta508 traffic/clathrin-coated vesicles formation (norm and CF) | 1.36E−02 | 1/19 | SH3GLB1 |
| #2 | Development_Osteopontin signaling in osteoclasts and | 2.15E−02 | 1/30 | SPP1 | |
| #2 | Apoptosis and survival_Granzyme A signaling | 2.15E−02 | 1/30 | GZMA | |
| #3 | Autophagy | 2.29E−02 | 1/32 | SH3GLB1 | |
| GeneGoProcess networks | #1 | Proteolysis: proteolysis in cell cycle and apoptosis | 1.01E−02 | 2/125 | GZMA, GZMK |
| #2 | Cytoskeleton: actin filaments | 1.95E−02 | 2/176 | PACSIN, PACSIN2 | |
| GeneOntology Processes | #1 | Cellular membrane organization | 1.01E−04 | 5/653 | SH3GLB1, CCDC88A, ITSN1, PACSIN, PACSIN2 |
| #2 | Membrane organization | 1.03E−04 | 5/656 | SH3GLB1, CCDC88A, ITSN1, PACSIN, PACSIN2 | |
| #3 | Negative regulation of cellular component organization | 1.61E−04 | 4/375 | MAP2, SPP1, PACSIN, PACSIN2 |