Figure 3.

Lifespan and mass of MBNL1-OE mice. (A) Kaplan–Meier survival plot for 14685 (n = 35 WT; n = 28 OE) and (B) 14686 (n = 26 WT; n = 23 OE) mice up to 78 weeks of age. No statistically significant difference in survival at any time point was observed in line 14685. Mice from line 14686 have a significant increase in percent mortality beginning at week 76 (P = 0.023). (C) Mass of 14685 and (D) 14686 mice (n >3 for all time points). No significant difference in mass was observed for line 14685 at any time point. In contrast, 14686 mice were smaller at 3–8 weeks (P < 0.005) and for week 9 (P = 0.011). Asterisks (*) indicate statistically significant differences.